I just received an interesting email from a client looking to make a career change. She asks whether a functional resume would be better than a traditional structure. She's thinking that she needs to distract employers from her background in one industry so they can imagine her in another ... the problem is that the readers are not stupid and they won't be fooled by 'clever' resume tricks.
The truth is that if you want to make a career change, you really need to go about it very differently from a normal search. Check out my article on career change for more information.
The key isn't a clever resume or a great cover letter, although these can't hurt. Successful career change really requires an aggressive networking and personal contact campaign.